Oleuropein in Olive and its Pharmacological Effects
نویسنده
چکیده
Olive from Olea europaea is native to the Mediterranean region and, both the oil and the fruit are some of the main components of the Mediterranean diet. The main active constituents of olive oil include oleic acid, phenolic constituents, and squalene. The main phenolic compounds, hydroxytyrosol and oleuropein, give extra-virgin olive oil its bitter, pungent taste. The present review focuses on recent works that have analyzed the relationship between the major phenolic compound oleuropein and its pharmacological activities including antioxidant, anti-inflammatory, anti-atherogenic, anti-cancer activities, antimicrobial activity, antiviral activity, hypolipidemic and hypoglycemic effect.
منابع مشابه
Olive (Olea europaea L.) leaf extract and its main component (oleuropein) mitigate the development of morphine physical dependence in rats
Introduction: Recently, it has been demonstrated that olive leaf extract and its main component have calcium channel blocker, anti-inflammatory and anti-oxidative properties. However, the effects of olive leaf extract on opioid dependence have not yet been clarified. Methods: To develop morphine dependence, morphine was injected twice daily for 7 days according to an escalating dose in rats...
متن کاملUnderstanding the Characteristics of Oleuropein for Table Olive Processing
Phenolic compounds make up 2-3% (w/w) of olive flesh, whose most abundant part is oleuropein which is responsible for the characteristic bitter taste of olive fruits. Oleuropein is a heterosidic ester of elenolic acid and hydroxytyrosol and possesses beneficial effects on human health. But most fundamental and important step of table olive processing is to reduce level of oleuropein because oli...
متن کاملStudy of the amount of oleuropein level in the leaves of olive varieties cultivated in Khorramabad (Iran)
Background: Oleuropein (OE) is the most abundant biophenol compounds in olive leaves and its healthy effects as a strong antioxidant is well known. The oleuropein level in olives depends upon cultivated variety, climate, place, time and the method of extraction. In Lorestan province, many varieties of olive have been cultivated that the study of OE level in their leaves, as whilst sources of th...
متن کاملComputer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins
Aging is associated with common conditions, including cancer, diabetes, cardiovascular disease, and Alzheimer's disease. The type of multi-targeted pharmacological approach necessary to address a complex multifaceted disease such as aging might take advantage of pleiotropic natural polyphenols affecting a wide variety of biological processes. We have recently postulated that the secoiridoids ol...
متن کاملEffects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes
BACKGROUND Olive oil and its minor constituents have been recommended as important dietary therapeutic interventions in preventive medicine. However, a question remains to be addressed: what are the effects of olive oil and its phenolic compounds on obesity-induced cardiac metabolic changes? METHODS Male Wistar rats were divided into two groups (n = 24/group): (C) receiving standard-chow; (Ob...
متن کامل